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2025

Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L

Pozzi L., Gotti A., Fumagalli M., Cittarella A., Fasano V., Paladino G., Ciriello U., Princiotto S., Annunziata F., Martinelli G., Sangiovanni E., Pinto A., Dell’Agli M., Passarella D.

J. Nat. Prod. 2025, 88, 10, 2451–2459

doi: 10.1021/acs.jnatprod.5c00826


Exploring Guanidinium Group Involvement in Hordatine Interactions with the G-Quadruplex Motif Within the c-MYC Promoter Region

Dozio D., Caccia A., Dallavalle S., Beretta G.L., Perego P., Artali R., Mazzini S., Princiotto S.

Int. J. Mol. Sci. 2025, 26(21), 10580

doi:10.3390/ijms262110580

5th Next Generation Biocatalysis Symposium (NextGenBiocat) in Milano, Italy


Contente M.L., Parmeggiani F.

ChemBioChem 2025, 26, e202500550 (1 of 5)

doi: 10.1002/cbic.202500550

Spinning Green: Lipase-Catalyzed Synthesis of Bioactive Fatty Acid Amides from Renewable Lipid Feedstocks in a Rotating Bed Reactor

Bigliardi M., Donzella S., Dăescu D.-I., Pellis A., Tamborini L., Pinto A., Contente M.L.


ACS Sustainable Chem. Eng. 2025, 13, 42, 18214–18222.

doi: 10.1021/acssuschemeng.5c07654

Cooperative Enhancement of Aldoxime Dehydratase Stability through Whole-Cell Immobilization and Flow Reactor Integration

Nespoli L., Donzella S., Bigliardi M., Contente M. L., Pinheiro de Souza Oliveira R., Romano D., Molinari F.

ChemBioChem 2025, 26, e202500618 (1 of 8)

doi: 10.1002/cbic.202500618

Streamlining Vorinostat Synthesis: A Chemoenzymatic Continuous Flow Approach

Annunziata F., Tamborini L., Pinto A., Christodoulou M.S., Dallavalle S., Princiotto S., Contente M.L.

Eur. J. Org. Chem., 2025, 28(27), e202500178

doi: 10.1002/ejoc.202500178

Chromenone Derivatives as CRM1 Inhibitors for Targeting Glioblastoma

Princiotto S., Jiménez L., Domínguez L., Sequeira J. G. N., Mourato C., Orea-Soufi A., Santos B., Dallavalle S., Machuqueiro M., Ferreira B. I., Link W.

Chembiochem, 2025, 26(15), e202500195

doi: 10.1002/cbic.202500195

Retargeting Gram-Positive-Only Adarotene-Derived Antibacterials to Broad-Spectrum Antibiotics

Princiotto S, Cutarella L., Fortuna A., Mellini M., Casciaro B., Loffredo M.R., Temprano A.G., Cappiello F., Leoni L., Mangoni M.L., Mori M., Musso L., Sacchi F., Pinna C., Rampioni G., Dallavalle S., Pisano C.

Antibiotics 2025, 14(9), 956

doi: 10.3390/antibiotics14090956

Reproducible Ala-Gly oligomerization catalyzed by the natural Borate colemanite in prebiotic conditions

Rimoldi I., Facchetti G., Feni L., Gatta G.D., Lotti P., Rizzato S., Christodoulou M.S., Silvestrini L., Lo Presti L.

Sci. Rep. 15, 29006 (2025)

doi: 10.1038/s41598-025-14072-2

Design, synthesis, and biological evaluation of chalcone derivatives as selective Monoamine Oxidase-B inhibitors with potential neuroprotective effects

Facchetti G. , Marchese S. , Coccè V. , Doneda L. , Alessandri G. , Paino F. , Pessina A. , Pinzi L. , Rastelli G. , Binda C. , Christodoulou M.S. , Rimoldi I.

Eur. J. Med. Chem. 2025, 298, 117990

doi: 10.1016/j.ejmech.2025.117990

UV-Shielding Biopolymer Coatings Loaded with Bioactive Compounds for Food Packaging Applications

Coatings 2025, 15(7), 741

Gennaro M., Büyükta D. , Carullo D., Pinto A. , Dallavalle S., Farris S.

doi: 10.3390/coatings15070741

New catalytic strategies for one-pot total synthesis of L-carnosine

Mol. Catal. 584 (2025) 115246

Facchetti G., Coffetti G., Christodoulou  M.S. ,  Arnal L., Rimoldi I.

doi: 10.1016/j.mcat.2025.115246

Preliminary Data on the Antiviral Activity of Helleborus bocconei subsp. intermedius Root Extracts Against Animal Herpesviruses

Microorganisms 2025, 13(4), 891

Galluzzo P., Di Bella S., Migliore S., Raimondi M.V., Bivacqua R., Borgonovo G., Princiotto S., Girgenti A., Palumbo L., Dara S., Guercio A., Alduina R., Loria G.R., Cannella V.

doi: 10.3390/microorganisms13040891

Antibacterial activity of tamoxifen derivatives against methicillin-resistant Staphylococcus aureus

Front. Pharmacol. 2025, Vol. 162025, Art. num. 1549288

Molina Panadero I., Falcón Torres J., Hmadcha A., Princiotto S., Cutarella L., Mori M., Dallavalle S., Christodoulou M. S., Smani Y.

doi: 10.3389/fphar.2025.1549288

Nature-Inspired Biphenyls and Diphenyl Ethers: Design, Synthesis, and Biological Evaluation

Sacchi F., Ghosh S., Dallavalle S., Fessas D., Cortesi P., Martino P.A., Starna J. L. E., Pinto A., Annunziata F., Princiotto S., Kunova A.

ACS Omega 2025, 10 (21), 22028–22035

doi: 10.1021/acsomega.5c02099

Mitochondria-targeted rosmarinic acid: Its role against oxidative damage

Girgenti A., Picone P., Buttacavoli M., Palumbo L., Naselli F., Presti E.L., Pecora D., Cipollina C., Annunziata F., Pinto A., Tamborini L., Nuzzo D.

Biomed Pharmacother 2025, 187, 118114

doi: 10.1016/j.biopha.2025.118114

Pioneering Women Shaping the Field of Biocatalysis

Benítez-Mateos, A. I. , Caroline E. P. , Schmidt, S., Contente, M.L.

ChemCatChem 2025, 0, e202500088

doi: 10.1002/cctc.202500088

Flow biocatalysis: a pathway to sustainable innovation

Bigliardi M., Contente M.L.

Biochem (Lond) (2025) 47 (1), 12–16

doi: 10.1042/bio_2024_936

Valorization of Apple Pomace: Production of Phloretin Using a Bacterial Cellulose-Immobilized β-Glycosidase

Colacicco A., Nespoli L., Ribul Moro E., Farris S., Molinari F., Romano D., Contente M.L.

ChemSusChem 2025, 00, e202500592

doi: 10.1002/cssc.202500592

Natural Antifungal Alkaloids for Crop Protection: An Overview of the Latest Synthetic Approaches

Dozio D., Sacchi F., Pinto A., Dallavalle S., Annunziata F., Princiotto S.

Pharmaceuticals, 2025, 18(4), 589

doi: 10.3390/ph18040589

Two-step flow amidation of natural phenolic acids as antiradical and antimicrobial agents

Pecora D.; Magni A.; Vicinanza S.; Annunziata F.; Princiotto S.; Donzella S.; Meroni G.; Martino P. A.; Basilico N.; Parapini S.; Conti P.; Borsari C.; Tamborini L.

Journal of Natural Products

doi: 10.1021/acs.jnatprod.5c00131

Assessing the impact of food-derived bioactives on digestive proteases by in vitro and in silico approaches

Borgonovi S.M.;  Perugino F.; Dellafiora L.; Annunziata F.;  Pedroni L.;  Galaverna G.;  Pinto A.; Dallavalle S.;  Iametti S.; Di Nunzio M.

Food and Function  2025, 16, 2959-2971

doi: 10.1039/D4FO04022H 

Enzymatic Deglycosylation and Lipophilization of Soy Glycosides into Value-Added Compounds for Food and Cosmetic Applications

Corti M.; Annunziata F.; Colacicco A.; Tamborini L.; Molinari F.; Contente M.L.; Pinto A.

ACS Omega 2025, 10 (12) 12417–12424

doi: 10.1021/acsomega.4c11325

Biocatalyzed Synthesis of Benzoyl and Cinnamoylamides Inspired by Rice Phytoalexins

Pinna C.; Nespoli L.; Brioschi G.; Kunova A.; Cortesi P.; Martino P.A.; Molinari F.; Musso L.; Dallavalle S.; Contente M.L.; Pinto A.

ACS Agric. Sci. Technol. 2025, 5 (4) 461–467

doi: 10.1021/acsagscitech.4c00380

Valorization of saffron waste as a natural source of 3-hydroxy-γ-butyrolactone, a valuable chiral building block for pharmaceutical applications

Corti M.; Princiotto S.; Zuccolo M.; Beretta G.;  Dallavalle S.; Pinto A.;  Annunziata F.;  Borgonovo G.

Tetrahedron Green Chem 2025, 100069

doi:10.1016/j.tgchem.2025.100069

Efficient and Versatile Flow Synthesis of New Nonionic Glucamide Surfactants

Pecora D.; Ballabio G.; Brioschi G.; Robescu M.S.; Semproli R.; Mapelli B.; Annunziata F.; Speranza G.; Cappelletti G.; Ubiali D.; Tamborini L.

ACS Omega 2025, 10 (7) 6976–6982

doi: 10.1021/acsomega.4c09871

Feruloyl-amides as natural antimicrobials for crop and food protection

Dozio D.; Ghosh S.; Consolini D.A.; Ermini J. L.; Pinto L.; Baruzzi F.; Contente M.L.; Pinto A.; Cortesi P.; Princiotto P.; Kunova A.; Dallavalle S.

Chemical and Biological Technologies in Agriculture

doi: 10.1186/s40538-025-00736-8

Oxidation of benzyl alcohol derivatives into carboxylic acids with a new Acetobacter malorum strain: boosting the productivity in a continuous flow system

Nespoli L.; Donzella S.; Moro E.R.; Mafezoli J.; Contente M.L.; Romano D.; Molinari F.

Molecular Catalysis 571 (2025) 114698

doi:10.1016/j.mcat.2024.114698